Prague Med. Rep. 2012, 113, 294-298

https://doi.org/10.14712/23362936.2015.13

Transfusion-related Acute Lung Injury: Report of Two Cases

Zuzana Čermáková1,2, M. Kořístka3, Š. Blahutová3, J. Dvořáčková2, R. Brát2, I. Valkovský2, R. Hrdličková3

11st Department of Medicine – Department of Hematology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
2Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
3Blood Centre, University Hospital Ostrava, Ostrava, Czech Republic

Received January 30, 2012
Accepted October 10, 2012

Transfusion-related acute lung injury (TRALI) is a severe life-threatening complication of blood transfusion, characterized by acute lung injury developing within 2–6 h of transfusion. However, TRALI is difficult to diagnose, and the initial report or suspicion of TRALI depends on close collaboration between clinical departments and transfusion centres. A total of 17 adverse post-transfusion reactions were reported to the Blood Centre of the University Hospital Ostrava as suspected TRALI between 2005 and 2010. We report two cases of serious TRALI with different pathogenetic mechanisms.

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