Prague Med. Rep. 2014, 115, 5-15

https://doi.org/10.14712/23362936.2014.1

Effects of a Single Dose of Erythropoietin on Motor Function and Cognition after Focal Brain Ischemia in Adult Rats

Michaela Hralová1, Eva Plaňanská2, Yvona Angerová3, Andrea Jadwiszczoková1, Jana Bortelová1, Marcela Lippertová-Grünerová3,4, Dana Marešová1,*

1Institute of Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
2Department of Neurology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
3Department of Rehabilitation Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
4Faculty of Medicine, University of Cologne, Cologne, Germany

References

1. Brines, M. L., Cerami, A. (2008) Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response. J. Intern. Med. 264, 405–432. <https://doi.org/10.1111/j.1365-2796.2008.02024.x>
2. Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lenarolle, N. C., Cerami, C., Itri, L. M., Cerami, A. (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci USA 97, 10526–10531. <https://doi.org/10.1073/pnas.97.19.10526> <PubMed>
3. Brines, M. L., Grasso, G., Fiordaliso, F., Sfacteria, A., Ghezzi, P., Fratelli, M., Latini, R., Xie, Q. W., Smart, J., Su-Rick, C. J., Pobre, E., Diaz, D., Gomez, D., Hand, C., Coleman, T., Cerami, A. (2004) Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor. Proc. Natl. Acad. Sci. USA 101, 14907–14912. <https://doi.org/10.1073/pnas.0406491101> <PubMed>
4. Buemi, M., Cavalero, E., Floccari, F., Sturiale, A., Aloisi, C., Trimarchi, M., Grasso, G., Corica, F., Frisina, N. (2002) Erythropoietin and the brain: from neurodevelopment to neuroprotection. Clin. Sci. (Lond.) 103, 275–282. <https://doi.org/10.1042/cs1030275>
5. Cherian, L., Goodmann, J. C., Robertson, C. (2011) Improved cerebrovascular function and reduced histological damage with darbepoetin alfa administration after cortical impact injury in rats. J. Pharmacol. Exp. Ther. 337, 451–456. <https://doi.org/10.1124/jpet.110.176602> <PubMed>
6. Digicaylioglu, M., Bichet, S., Marti, H. H., Wenger, R. H., Rivas, L. A., Bauer, C., Gassmann, N. M. (1995) Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc. Natl. Acad. Sci. USA 92, 3717–3720. <https://doi.org/10.1073/pnas.92.9.3717> <PubMed>
7. Fitzgerald, A., Aditya, H., Prior, A., McNeill, S., Pentland, B. (2010) Anoxic brain injury: Clinical patterns and functional outcomes. A study of 93 cases. Brain Inj. 24, 1311–1323. <https://doi.org/10.3109/02699052.2010.506864>
8. Fuxe, K., Bjelke, B., Andbjer, B., Grahn, H., Rimondini, R., Agnati, L. F. (1997) Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia. Neuroreport 8, 2623–2629. <https://doi.org/10.1097/00001756-199707280-00040>
9. Gauggel, S., Peleska, S., Bode, P. (2000) Relationship between cognitive impairments and rated activity restrictions in stroke patients. J. Head Trauma Rehabil. 15, 710–723. <https://doi.org/10.1097/00001199-200002000-00009>
10. Hartley, C. E., Vaema, M., Fischer, J. P., Riccardi, R., Strauss, J. A., Shah, S., Zhang, S., Yang, Z. J. (2008) Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma. J. Neurosurg. 109, 708–714. <https://doi.org/10.3171/JNS/2008/109/10/0708>
11. Hralová, M., Marešová, D., Riljak, V. (2011) Is learning ability and spatial memory in rats influenced by single dose of nicotine? Prague Med. Rep. 112, 193–204.
12. Jelkmann, W. (2004) Molecular biology and erythropoietin. Intern. Med. 43, 649–659. <https://doi.org/10.2169/internalmedicine.43.649>
13. Klement, D., Blahna, K., Nekovářová, T. (2008) Novel behavioral tasks for studying spatial cognition in rats. Physiol. Res. 57, S161–S165.
14. Lacombe, C., Mayeux, P. (1998) Biology of erythropoietin. Haematologica 83, 724–732.
15. Lippert-Grüner, M., Maegele, M., Pokorný, J., Angelov, D. N., Švestková, O., Wittner, M., Trojan, S. (2007) Early rehabilitation model shows positive effect on neural degeneration and recovery from neuromotor deficits following traumatic brain injury. Physiol. Res. 56, 359–368.
16. Lipton, S. A. (2007) Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 8, 803–808. <https://doi.org/10.1038/nrn2229>
17. Mammis, A., McIntosh, T. K., Maniker, A. H. (2009) Erythropoietin as a neuroprotective agent in traumatic brain injury: Review. Surg. Neurol. 71, 527–531. <https://doi.org/10.1016/j.surneu.2008.02.040>
18. Mareš, J. (1995) Některé modely fokální hypoxie CNS. Čs. Fyziol. 44, 183–187.
19. Marti, H. H. (2004) Erythropoietin and the hypoxic brain. J. Exp. Biol. 207, 3233–3242. <https://doi.org/10.1242/jeb.01049>
20. Marti, H. H., Bernardin, M., Petit, E., Bauer, C. (2000) Neuroprotection and angiogenesis: Dual role of erythropoietin in brain ischemia. News Physiol. Sci. 15, 225–229.
21. Morrison, V., Pollard, B., Johnston, M., MacWalter, R. (2005) Anxiety and depression 3 years following stroke: demographic, clinical and psychological predictors. J. Psychosom. Res. 59, 209–213. <https://doi.org/10.1016/j.jpsychores.2005.02.019>
22. Murphy, J. M., Horton, N. J., Laird, N. M., Monson, R., Sobol, A., Leighton, A. (2004) Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution and comorbidity. Acta Psychiatr. Scand. 109, 355–375. <https://doi.org/10.1111/j.1600-0447.2003.00286.x>
23. Nithianantharajan, J., Hannan, A. J. (2006) Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat. Rev. Neurosci. 7, 697–709. <https://doi.org/10.1038/nrn1970>
24. Osredkar, D., Sall, J. W., Bickler, P. E., Ferriero, D. M. (2010) Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol. Dis. 38, 259–265. <https://doi.org/10.1016/j.nbd.2010.01.015> <PubMed>
25. Paschos, N., Lykissas, M. G., Beris, A. E. (2008) The role of erythropoietin as an inhibitor of tissue ischemia. Int. J. Biol. Sci. 4, 161–168. <https://doi.org/10.7150/ijbs.4.161> <PubMed>
26. Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., Fullerton, H. J., Gillespie, C., Hailpern, S. M., Heit, J. A., Howard, V. J., Kissela, B. M., Kittner, S. J., Lackland, D. T., Lichtman, J. H., Lisabeth, L. D., Makuc, D. M., Marcus, G. M., Marelli, A., Matchar, D. B., Moy, C. S., Mozaffarian, D., Mussolino, M. E., Nichol, G., Paynter, N. P., Soliman, E. Z., Sorlie, P. D., Sotoodehnia, N., Turan, T. N., Virani, S. S., Wong, N. D., Woo, D., Turner, M. B. (2012) Heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation 125, e2–e220.
27. Sargin, D., El-Kordi, A., Agarwal, A., Müller, M., Wojcik, S. M., Hassouna, I., Sperling, S., Nave, K. A., Ehrenreich, H. (2011) Expression of constitutively active erythropietin receptor in pyramidal neurons of cortex and hippocampus boots higher cognitive functions in mice. BMC Biol. 9, 27. <https://doi.org/10.1186/1741-7007-9-27> <PubMed>
28. Semenza, G. L. (2001) HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13, 167–171. <https://doi.org/10.1016/S0955-0674(00)00194-0>
29. Sharp, F. R., Bernaudin, M. (2004) HIF1 and oxygen sensing in the brain. Nat. Rev. Neurosci. 5, 437–448. <https://doi.org/10.1038/nrn1408>
30. Sicard, K., Fischer, M. (2009) Animal models of focal brain ischemia. Exp. Transl. Stroke Med. 13, 1–7.
31. Sola, A., Rogido, M., Lee, B. H., Genetta, T., Wen, T. C. (2005) Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats. Pediatr. Res. 57, 481–487. <https://doi.org/10.1203/01.PDR.0000155760.88664.06>
32. Strong, K., Mathers, C., Bonita, R. (2007) Preventing stroke: saving lives around the word. Lancet Neurol. 6, 182–187. <https://doi.org/10.1016/S1474-4422(07)70031-5>
33. Sveen, U., Bautz-Holter, E., Soedring, K. M., Wyller, T. B., Laake, K. (2003) Association between impairments, self-care ability and social activities 1 year after stroke. Disabil. Rehabil. 21, 372–377. <https://doi.org/10.1080/096382899297477>
34. Tateno, A., Murata, Y., Robinson, R. (2002) Comparison of cognitive impairment associated with major depression following stroke versus traumatic brain injury. Psychosomatics 43, 295–301. <https://doi.org/10.1176/appi.psy.43.4.295>
35. Thal, S. C., Mebmer, K., Schmidt-Elsaesser, R., Zausinger, S. (2008) Neurological impairment in rats after subarachnoid hemorrhage – a comparison of functional tests. J. Neurol. Sci. 268, 150–159. <https://doi.org/10.1016/j.jns.2007.12.002>
36. Visser-Keizer, A. C., Meyboom-de Jong, B., Deelman, B. G., Berg, I. J., Gerritsen, M. J. J. (2002) Subjective changes in emotion, cognition and behaviour after stroke: factors affecting the perception of patients and partners. J. Clin. Exp. Neuropsychol. 24, 1032–1045. <https://doi.org/10.1076/jcen.24.8.1032.8383>
37. Xiong, Y., Lu, D., Qu, C., Goussev, A., Schallert, T., Mahmood, A., Chopp, M. (2008) Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice. J. Neurosurg. 109, 510–521. <https://doi.org/10.3171/JNS/2008/109/9/0510> <PubMed>
38. Xu, F., Yu, Z. Y., Gind, L., Zheng, S. Y. (2012) Experimental studies of erythropoietin protection following traumatic brain injury in rats. Exp. Ther. Med. 4, 977–982. <https://doi.org/10.3892/etm.2012.723> <PubMed>
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