Prague Med. Rep. 2014, 115, 134-140

https://doi.org/10.14712/23362936.2014.44

Is the Small Size of a Breast Cancer Tumor the Crucial Point for Successful Medical Treatment?

Marie Strunová1, David Pavlišta1, Jitka Kobilková1, Jiří Pokorný2, Miloslav Janoušek1, Lenka Bauerová3, Anna Jandová1

1Department of Obstetrics and Gynaecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
2Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
3Institute of Pathology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic

Received July 1, 2014
Accepted November 18, 2014

References

1. Ahn, S., Lee, Y.-Y., Sung, J.-Y., Lee, J. J., Oh, Y. L., Sung, C. O., Song, S. Y. (2012) Body mass index and outcome of ASC-H-interpreted cervical smears in postmenopausal women. Acta Cytol. 56(3), 259–265. <https://doi.org/10.1159/000337448>
2. Kaplon, J., Zheng, L., Meissl, K., Chaneton, B., Serlivanov, V. A., Mackay, G., van der Burg, S. H., Verdegaal, E. M. E., Cascante, M., Shlomi, T., Gottlieb, E., Peeper, D. S. (2013) A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature 498, 109–112. <https://doi.org/10.1038/nature12154>
3. Kobilková, J. (1967) Cytological study of the level of estrogen during the reproductive age. Acta Cytol. 11, 497–512.
4. Kobilková, J., Filipovičová, M., Papež, L., Kvapil, F. (1977) Zytologische Bilder der hormonalen Situation bei Frauen mit Brustdrussentumoren. Arch. Geschwulstforsch. 47(7), 641–648.
5. Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A. K., Frank, P. G., Casimiro, M. C., Wang, C., Fortina, P., Addya, S., Pestell, R. G., Martinez-Outschoorn, U. E., Sotgia, F., Lisanti, M. P. (2009) Reverse Warburg effect. Aerobic glycolysis and cancer associated fibroblasts and their tumor stroma. Cell Cycle 8(23), 3984–4001. <https://doi.org/10.4161/cc.8.23.10238>
6. Pavlides, S., Tsirigos, A., Migneco, G., Whitaker-Menezes, D., Chiavarina, B., Flomenberg, N., Frank, P. G., Casimiro, M. C., Wang, C., Pestell, R. G., Martinez-Outschoorn, U. E., Howell, A., Sotgia, F., Lisanti, M. P. (2010) The autophagic tumor stroma model of cancer. Role of oxidative stress and ketone production in fuelling tumor cell metabolism. Cell Cycle 9(17), 3485–3505. <https://doi.org/10.4161/cc.9.17.12721> <PubMed>
7. Pavlišta, D., Eliška, O. (2005) Cutaneus and subcutaneous lymphatic drainage of the breast. Lymphology 38(2), 92–102.
8. Pavlišta, D., Eliška, O. (2012) Relationship between the lymphatic drainage of the breast and upper extremity. A post mortem study. Ann. Surg. Oncol. 19(11), 3410–3415. <https://doi.org/10.1245/s10434-012-2363-x>
9. Pokorný, J., Jandová, A., Nedbalová, M., Jelínek, F., Cifra, M., Kučera, O., Havelka, D., Vrba, J., Vrba, J. Jr., Čoček, A., Kobilková, J. (2012) Mitochondrial metabolism – Neglected link of cancer transformation and treatment. Prague Med. Rep. 113(2), 81–94. <https://doi.org/10.14712/23362936.2015.24>
10. Pokorný, J., Foletti, A., Kobilková, J., Jandová, A., Vrba, J., Vrba, J. Jr., Nedbalová, M., Čoček, A., Danani, A., Tuszynski, J. A. (2013a) Biophysical insight into cancer transformation and treatment. Scientific World Journal 2013, doi:10.1155/2013/195028. <https://doi.org/10.1155/2013/195028> <PubMed>
11. Pokorný, J., Pokorný, J. Jr., Kobilková, J. (2013b) Postulates on electromagnetic activity in biological systems and cancer. Integr. Biol. (Camb.) 5(12), 1439–1446. <https://doi.org/10.1039/c3ib40166a>
12. Schafer, M., Werner, S. (2008) Cancer as an overhealing wound an old hypothesis revised. Nat. Rev. Mol. Cell Biol. 9, 628–638. <https://doi.org/10.1038/nrm2455>
13. Slezák, M. (2013) Fighting cancer Darwin’s way. Evolutionary medicine. New Sci. 7, 12–19.
14. Sotgia, F., Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Flomenberg, N., Birbe, R. C., Witkiewicz, A. K., Howell, A., Philp, N. J., Pestell, R. G., Lisanti, M. P. (2012) Mitochondrial metabolism in cancer metastasis. Visualizing tumor cell mitochondria and the “reverse Warburg effect” in positive lymph node tissue. Cell Cycle 11, 1445–1454. <https://doi.org/10.4161/cc.19841> <PubMed>
15. Warburg, O. (1956) On the origin of cancer cells. Science 123, 309–314. <https://doi.org/10.1126/science.123.3191.309>
16. Warburg, O., Posener, K., Negelein, E. (1924) Über den Stoffwechsel der Carcinomzelle. Biochem. Z. 152, 309–344. (in German)
17. Witkiewicz, A. K., Whitaker-Menezes, D., Dasgupta, A., Philp, N. J., Lin, Z., Gandara, R., Sneddon, S., Martinez-Outschoorn, U. E., Sotgia, F., Lisanti, M. P. (2012) Using the “reverse Warburg effect” to identify high-risk breast cancer patients. Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers. Cell Cycle 11, 1108–1117. <https://doi.org/10.4161/cc.11.6.19530> <PubMed>
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