Prague Med. Rep. 2015, 116, 5-15

https://doi.org/10.14712/23362936.2015.40

Importance of Choline as Essential Nutrient and Its Role in Prevention of Various Toxicities

Somava Biswas, Sarbani Giri

Department of Life Science and Bioinformatics, Assam University, Silchar, India

Received November 2, 2014
Accepted March 12, 2015

References

1. Bagnyukova, T. V., Powell, C. L., Pavliv, O., Tryndyak, V. P., Pogribny, I. P. (2008) Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet. Brain Res. 1237, 44–51. <https://doi.org/10.1016/j.brainres.2008.07.073>
2. Ballard, M. S., Sun, M., Ko, J. (2012) Vitamin A, folate, and choline as a possible preventive intervention to fetal alcohol syndrome. Med. Hypotheses 78, 489–493. <https://doi.org/10.1016/j.mehy.2012.01.014>
3. Batra, V., Paul, T., Devasagayam, A. (2009) Interaction between cytotoxic effects of radiation and folate deficiency in relation to choline reserves. Toxicology 255, 91–99. <https://doi.org/10.1016/j.tox.2008.10.008>
4. Blusztajn, J. K., Zeisel, S. H., Wurtman, R. J. (1985) Developmental changes in the activity of phosphatidylethanolamine N-methyltransferases in rat brain. Biochem. J. 232, 505–511. <https://doi.org/10.1042/bj2320505> <PubMed>
5. Cheng, W.-L., Holmes-Mc Nary, M. Q., Mar, M.-H., Lien, E. L., Zeisel, S. H. (1996) Bioavailability of choline and choline esters from milk in rat pups. J. Nutr. Biochem. 7, 457–464. <https://doi.org/10.1016/0955-2863(96)00079-4>
6. Cohen, E. L., Wurtman, R. J. (1975) Brain acetylcholine: increase after systemic choline administration. Life Sci. 16(7), 1095–1102. <https://doi.org/10.1016/0024-3205(75)90194-0>
7. Corbin, K. D., Zeisel, S. H. (2012) Choline metabolism provides novel insights into non-alcoholic fatty liver disease and its progression. Curr. Opin. Gastroenterol. 28(2), 159–165. <https://doi.org/10.1097/MOG.0b013e32834e7b4b> <PubMed>
8. Craciunescu, C. N., Albright, C. D., Mar, M. H., Song, J., Zeisel, S. H. (2003) Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J. Nutr. 133(11), 3614–3618. <https://doi.org/10.1093/jn/133.11.3614> <PubMed>
9. da Costa, K. A., Kozyreva, O. G., Song, J., Galanko, J. A., Fischer, L. M., Zeisel, S. H. (2006) Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J. 20, 1336–1344. <https://doi.org/10.1096/fj.06-5734com> <PubMed>
10. FitzGerald, J., Moureau, S., Drogaris, P., O’Connell, E., Abshiru, N., Verreault, A., Thibault, P., Grenon, M., Lowndes, N. F. (2011) Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor. PLoS One 6(2), e14714. <https://doi.org/10.1371/journal.pone.0014714> <PubMed>
11. Food and Nutrition Board (Institute of Medicine) (1998) Dietary Reference Intakes for Folate, Thiamin, Riboflavin, Niacin, Vitamin B12, Pantothenic Acid, Biotin and Choline. National Academy Press, Washington, D.C.
12. Fu, A. L., Li, Q., Dong, Z. H., Huang, S. J., Wang, Y. X., Sun, M. J. (2004) Alternative therapy of Alzheimer’s disease via supplementation with choline acetyltransferase. Neurosci. Lett. 368, 258–262. <https://doi.org/10.1016/j.neulet.2004.05.116>
13. Garner, S. C., Mar, M. H., Zeisel, S. H. (1995) Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. J. Nutr. 125(11), 2851–2858.
14. Glenn, M. J., Gibson, E. M., Kirby, E. D., Mellott, T. J., Blusztajn, J. K., Williams, C. L. (2007) Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. Eur. J. Neurosci. 25(8), 2473–2482. <https://doi.org/10.1111/j.1460-9568.2007.05505.x> <PubMed>
15. Glenn, M. J., Adams, R. S., McClurg, L. (2012) Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats. Brain Res. 1443, 52–63. <https://doi.org/10.1016/j.brainres.2012.01.018> <PubMed>
16. Haubrich, D. R., Wedeking, P. W., Wang, P. F. (1974) Increase in tissue concentration of acetylcholine in guinea pigs in vivo induced by administration of choline. Life Sci. 14(5), 921–927. <https://doi.org/10.1016/0024-3205(74)90081-2>
17. Jensen, H. H., Batres-Marquez, S. P., Carriquiry, A., Schalinske, K. L. (2007) Choline in the diets of the U.S. population: NHANES, 2003–2004. FASEB J. 21, lb219.
18. Le Kim, D., Betzing, H. (1976) Intestinal absorption of polyunsaturated phosphatidyl-choline in the rat. Hoppe Seylers Z. Physiol. Chem. 357, 1321–1331. <https://doi.org/10.1515/bchm2.1976.357.2.1321>
19. Li, Q., Guo-Ross, S., Lewis, D. V., Turner, D., White, A. M., Wilson, W. A., Swartzwelder, H. S. (2004) Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. J. Neurophysiol. 191, 1545–1555. <https://doi.org/10.1152/jn.00785.2003>
20. Li, Z., Vance, D. (2008) Phosphatidylcholine and choline homeostasis. J. Lipid Res. 49, 1187–1194. <https://doi.org/10.1194/jlr.R700019-JLR200>
21. Loughery, J. E., Dunne, P. D., O’Neill, K. M., Meehan, R. R., McDaid, J. R., Walsh, C. P. (2011) DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response. Hum. Mol. Genet. 20, 3241–3255. <https://doi.org/10.1093/hmg/ddr236>
22. LSRO/FASEB (Life Sciences Research Office/Federation of American Societies for Experimental Biology) (1981) Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Report PB-82-133257.
23. Meck, W. H., Williams, C. L. (2003) Metabolic imprinting of choline by its availability during gestation: Implications for memory and attentional processing across the lifespan. Neurosci. Biobehav. Rev. 27, 385–399. <https://doi.org/10.1016/S0149-7634(03)00069-1>
24. Mellott, T. J., Follettie, M. T., Diesl, V., Hill, A. A., Lopez-Coviella, I., Blusztago, J. K. (2007) Prenatal choline availability modulated hippocampal and cerebral cortical gene expression. FASEB J. 21, 1311–1323. <https://doi.org/10.1096/fj.06-6597com>
25. Nag, N., Mellott, T. J., Berger-Sweeney, J. E. (2008) Effects of postnatal dietary choline supplementation on motor regional brain volume and growth factor expression in a mouse model of Rett syndrome. Brain Res. 1237, 101–109. <https://doi.org/10.1016/j.brainres.2008.08.042>
26. Nitsch, R. M., Blusztajn, J. K., Pittas, A. G., Slack, B. E., Growdon, J. H., Wurtman, R. J. (1992) Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci. U. S. A. 89, 1671–1675. <https://doi.org/10.1073/pnas.89.5.1671> <PubMed>
27. Ossani, G., Dalgh, M., Repetto, M. (2007) Oxidative damage lipid peroxidation in the kidney of choline-deficient rats. Front. Biosci. 12, 1174–1183. <https://doi.org/10.2741/2135>
28. Pogribny, I. P., Shpyleva, S. I., Muskhelishvili, L., Bagnyukova, T. V., James, S. J., Beland, F. A. (2009) Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet. Mutat. Res. 669, 56–62. <https://doi.org/10.1016/j.mrfmmm.2009.05.003>
29. Powell, C. L., Kosyk, O., Bradford, B. U., Parker, J. S., Lobenhofer, E. K., Denda, A., Uematsu, F., Nakae, D., Rusyn, L. (2005) Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury. Hepatology 42, 1137–1147. <https://doi.org/10.1002/hep.20910>
30. Repetto, M. G., Ossani, G., Monserrat, A. J., Boveris, A. (2010) Oxidative damage: The biochemical mechanism of cellular injury and necrosis in choline deficiency. Exp. Mol. Pathol. 88, 143–149. <https://doi.org/10.1016/j.yexmp.2009.11.002>
31. Resseguie, M., Song, J., Niculescu, M. D., da Costa, K. A., Randall, T. A., Zeisel, S. H. (2007) Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J. 21, 2622–2632. <https://doi.org/10.1096/fj.07-8227com> <PubMed>
32. Resseguie, M. E., da Costa, K. A., Galanko, J. A., Patel, M., Davis, I. J., Zeisel, S. H. (2011) Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J. Biol. Chem. 286, 1649–1658. <https://doi.org/10.1074/jbc.M110.106922> <PubMed>
33. Schugar, R. C., Huang, X., Moll, A. R., Brunt, E. M., Crawford, P. A. (2013) Role of choline deficiency in the fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. PLoS One 8(8), e74806. <https://doi.org/10.1371/journal.pone.0074806> <PubMed>
34. Shaw, G. M., Carmichael, S. L., Yang, W., Selvin, S., Schaffer, D. M. (2004) Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am. J. Epidemiol. 160, 102–109. <https://doi.org/10.1093/aje/kwh187>
35. Shaw, G. M., Carmichael, S. L., Laurent, C., Rasmussen, S. A. (2006) Maternal nutrient intakes and risk of orofacial clefts. Epidemiology 17, 285–291. <https://doi.org/10.1097/01.ede.0000208348.30012.35>
36. Shinohara, Y., Hasegawa, H., Ogawa, K., Tagoku, K., Hashimoto, T. (2006) Distinct effects of folate and choline deficiency on plasma kinetics of methionine and homocysteine in rats. Metabolism 55, 899–906. <https://doi.org/10.1016/j.metabol.2006.02.017>
37. Shronts, E. P. (1997) Essential nature of choline with implications for total parental nutrition. J. Am. Diet. Assoc. 97(6), 639–646, 649. <https://doi.org/10.1016/S0002-8223(97)00161-2>
38. Song, G., Cui, Y., Han, Z. J., Xia, H. F., Ma, X. (2012) Effects of choline on sodium arsenite-induced neural tube defects in chick embryos. Food Chem. Toxicol. 50(12), 4364–4374. <https://doi.org/10.1016/j.fct.2012.08.023>
39. Stevens, K. E., Adams, C. E., Mellott, T. J., Robbins, E., Kisley, M. A. (2008) Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. Brain Res. 1237, 84–90. <https://doi.org/10.1016/j.brainres.2008.08.047> <PubMed>
40. Thomas, J. D., Abou, E. J., Dominguez, H. D. (2009) Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicol. Teratol. 31(5), 303–311. <https://doi.org/10.1016/j.ntt.2009.07.002> <PubMed>
41. Thomas, J. D., Idrus, N. M., Monk, B. R., Dominguez, H. D. (2010) Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. Birth Defects Res. A Clin. Mol. Teratol. 88(10), 827–837. <https://doi.org/10.1002/bdra.20713> <PubMed>
42. Ward, B. C., Kolodny, N. H., Nag, N., Berger-Sweeney, J. E. (2009) Neurochemical changes in a mouse model of Rett syndrome: Changes over time and in response to perinatal choline nutritional supplementation. J. Neurochem. 108, 361–371. <https://doi.org/10.1111/j.1471-4159.2008.05768.x>
43. Wecker, L. (1986) Neurochemical effects of choline supplementation. Can. J. Physiol. Pharmacol. 64(3), 329–333. <https://doi.org/10.1139/y86-054>
44. Zeisel, S. H. (2006a) Choline: Critical role during fetal development and dietary requirements in adults. Annu. Rev. Nutr. 26, 229–250. <https://doi.org/10.1146/annurev.nutr.26.061505.111156> <PubMed>
45. Zeisel, S. H. (2006b) The fetal origins of memory: The role of dietary choline in optimal brain development. J. Pediatr. 149, S131–S136. <https://doi.org/10.1016/j.jpeds.2006.06.065> <PubMed>
46. Zeisel, S. H. (2012) Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat. Res. 733, 34–38. <https://doi.org/10.1016/j.mrfmmm.2011.10.008> <PubMed>
47. Zeisel, S. H., Blusztajn, J. K. (1994) Choline and human nutrition. Annu. Rev. Nutr. 14, 269–296. <https://doi.org/10.1146/annurev.nu.14.070194.001413>
48. Zeisel, S. H., da Costa, K. A. (2009) Choline: An essential nutrient for public health. Nutr. Rev. 67(11), 615–623. <https://doi.org/10.1111/j.1753-4887.2009.00246.x> <PubMed>
49. Zeisel, S. H., Char, D., Sheard, N. F. (1986) Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas. J. Nutr. 116, 50–58. <https://doi.org/10.1093/jn/116.1.50>
50. Zeisel, S. H., Mar, M. H., Howe, J., Holden, J. (2003) Concentrations of choline-containing compounds and betaine in common foods. J. Nutr. 133, 1302–1307. <https://doi.org/10.1093/jn/133.5.1302>
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