Prague Med. Rep. 2015, 116, 24-30

https://doi.org/10.14712/23362936.2015.42

Possible Association between Erectile Dysfunction and Osteoporosis in Men

Murat Dursun1, Emin Özbek2, Alper Otunctemur2, Suleyman Sami Cakir3

1Department of Urology, Bahcelievler State Hospital, Istanbul, Turkey
2Department of Urology, Okmeydani Research and Education Hospital, Istanbul, Turkey
3Department of Urology, Bayburt State Hospital, Bayburt, Turkey

Received October 26, 2014
Accepted March 12, 2015

References

1. Alexander, G. M., Sherwin, B. B. (1991) The association between testosterone, sexual arousal, and selective attention for erotic stimuli in men. Horm. Behav. 25, 367–381. <https://doi.org/10.1016/0018-506X(91)90008-6>
2. Amin, S. (2003) Male osteoporosis: epidemiology and pathophysiology. Curr. Osteoporos. Rep. 1, 71–77. <https://doi.org/10.1007/s11914-003-0012-9>
3. Andric, S. A., Janjic, M. M., Stojkov, N. J., Kostic, T. S. (2010) Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cells. Biol. Reprod. 83(3), 434–442. <https://doi.org/10.1095/biolreprod.110.083626>
4. Auharek, S. A., Lara, N. L., Avelar, G. F., Sharpe, R. M., França, L. R. (2012) Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development. Int. J. Androl. 35(5), 741–751. <https://doi.org/10.1111/j.1365-2605.2012.01264.x>
5. Ayta, I. A., McKinlay, J. B., Krane, R. J. (1999) The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int. 84, 50–56. <https://doi.org/10.1046/j.1464-410x.1999.00142.x>
6. Barkin, J. (2010) Erectile dysfunction and low testosterone: cause or an effect? Can. J. Urol. 17, 2–11 (Suppl. 1).
7. Bhasin, S., Enzlin, P., Coviello, A., Basson, R. (2007) Sexual dysfunction in men and women with endocrine disorders. Lancet 369, 597–611. <https://doi.org/10.1016/S0140-6736(07)60280-3>
8. Brandi, M. L., Hukkanen, M., Umeda, T., Moradi-Bidhendi, N., Bianchi, S., Gross, S. S., Polak, J. M., MacIntyre, I. (1995) Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc. Natl. Acad. Sci. U. S. A. 92, 2954–2958. <https://doi.org/10.1073/pnas.92.7.2954> <PubMed>
9. Burnett, A. L. (1995) Role of nitric oxide in the physiology of erection. Biol. Reprod. 52, 485–489. <https://doi.org/10.1095/biolreprod52.3.485>
10. Burnett, A. L., Lowenstein, C. J., Bredt, D. S., Chang, T. S., Snyder, S. H. (1992) Nitric oxide: a physiologic mediator of penile erection. Science 257, 401–403. <https://doi.org/10.1126/science.1378650>
11. Dong, J. Y., Zhang, Y. H., Qin, L. Q. (2011) Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies. J. Am. Coll. Cardiol. 58, 1378–1385. <https://doi.org/10.1016/j.jacc.2011.06.024>
12. Dong, S. S., Williams, J. P., Jordan, S. E., Cornwell, T., Blair, H. C. (1999) Nitric oxide regulation of cGMP production in osteoclasts. J. Cell. Biochem. 73, 478–487. <https://doi.org/10.1002/(SICI)1097-4644(19990615)73:4<478::AID-JCB6>3.0.CO;2-T>
13. Dupree, K., Dobs, A. (2004) Osteopenia and male hypogonadism. Rev. Urol. 6, S30–S34 (Suppl. 6).
14. Dy, C. J., Lamont, L. E., Ton, Q. V., Lane, J. M. (2011) Sex and gender considerations in male patients with osteoporosis. Clin. Orthop. Relat. Res. 469, 1906–1912. <https://doi.org/10.1007/s11999-011-1849-3> <PubMed>
15. Fisher, W. A., Eardley, I., McCabe, M., Sand, M. (2009) Erectile dysfunction (ED) is a shared sexual concern of couples I: couple conceptions of ED. J. Sex. Med. 6, 2746–2760. <https://doi.org/10.1111/j.1743-6109.2009.01457.x>
16. Francis, R. M., Peacock, M., Aaron, J. E., Selby, P. L., Taylor, G. A., Thompson, J., Marshall, D. H., Horsman, A. (1986) Osteoporosis in hypogonadal men: role of decreased plasma 1,25dihydroxyvitamin D, calcium malabsorption, and low bone formation. Bone 7, 261–268. <https://doi.org/10.1016/8756-3282(86)90205-X>
17. Gonzalez-Cadavid, N. F., Ignarro, L. J., Rajfer, J. (1999) Nitric oxide and the cyclic GMP system in the penis. Mol. Urol. 3, 51–59.
18. Joannides, R., Haefeli, W. E., Linder, L., Richard, V., Bakkali, E. H., Thuillez, C., Lüscher, T. F. (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91, 1314–1319. <https://doi.org/10.1161/01.CIR.91.5.1314>
19. Johannes, C. B., Araujo, A. B., Feldman, H. A., Derby, C. A., Kleinman, K. P., McKinlay, J. B. (2000) Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study. J. Urol. 163, 460–463. <https://doi.org/10.1016/S0022-5347(05)67900-1>
20. Kasten, T. P., Collin-Osdoby, P., Patel, N., Osdoby, P., Krukowski, M., Misko, T. P., Settle, S. L., Currie, M. G., Nickols, G. A. (1994) Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 91, 3569–3573. <https://doi.org/10.1073/pnas.91.9.3569> <PubMed>
21. Kelly, P. J., Montgomery, R. J., Bronk, J. T. (1990) Reaction of the circulatory system to injury and regeneration. Clin. Orthop. Relat. Res. 254, 275–288.
22. Looker, A. C., Mussolino, M. E. (2008) Serum 25-hydroxyvitamin D and hip fracture risk in older U.S. white adults. J. Bone Miner. Res. 23, 143–150. <https://doi.org/10.1359/jbmr.071003>
23. MacIntyre, I., Zaidi, M., Alam, A. S., Datta, H. K., Moonga, B. S., Lidbury, P. S., Hecker, M., Vane, J. R. (1991) Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc. Natl. Acad. Sci. U. S. A. 88, 2936–2940. <https://doi.org/10.1073/pnas.88.7.2936> <PubMed>
24. Marin, D. P., Bolin, A. P., dos Santos Rde, C., Curi, R., Otton, R. (2010) Testosterone suppresses oxidative stress in human neutrophils. Cell Biochem. Funct. 28(5), 394–402. <https://doi.org/10.1002/cbf.1669>
25. Montorsi, F., Adaikan, G., Becher, E., Giuliano, F., Khoury, S., Lue, T. F., Sharlip, I., Althof, S. E., Andersson, K. E., Brock, G., Broderick, G., Burnett, A., Buvat, J., Dean, J., Donatucci, C., Eardley, I., Fugl-Meyer, K. S., Goldstein, I., Hackett, G., Hatzichristou, D., Hellstrom, W., Incrocci, L., Jackson, G., Kadioglu, A., Levine, L., Lewis, R. W., Maggi, M., McCabe, M., McMahon, C. G., Montague, D., Motorsi, P., Mulhall, J., Pfaus, J., Porst, H., Ralph, D., Rosen, R., Rowland, D., Sadeghi-Nejad, H., Shabsigh, R., Stief, C., Vardi, Y., Wallen, K., Wasserman, M. (2010) Summary of the recommendations on sexual dysfunctions in men. J. Sex. Med. 7, 3572–3588. <https://doi.org/10.1111/j.1743-6109.2010.02062.x>
26. Morales, A., Heaton, J. P. W. (2003) Hypogonadism and erectile dysfunction: pathophysiological observations and therapeutic outcomes. BJU Int. 92, 896–899. <https://doi.org/10.1111/j.1464-410X.2003.04532.x>
27. Palmer, R. M., Ferrige, A. G., Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524–526. <https://doi.org/10.1038/327524a0>
28. Papaioannou, A., Kennedy, C. C., Cranney, A., Hawker, G., Brown, J. P., Kaiser, S. M., Leslie, W. D., O’Brien, C. J., Sawka, A. M., Khan, A., Siminoski, K., Tarulli, G., Webster, D., McGowan, J., Adachi, J. D. (2009) Risk factors for low BMD in healthy men age 50 years or older: a systematic review. Osteoporos. Int. 20, 507–518. <https://doi.org/10.1007/s00198-008-0720-1> <PubMed>
29. Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., Ignarro, L. J. (1992) Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med. 326, 90–94. <https://doi.org/10.1056/NEJM199201093260203>
30. Ralston, S. H., Ho, L. P., Helfrich, M. H., Grabowski, P. S., Johnston, P. W., Benjamin, N. (1995) Nitric oxide: a cytokine-induced regulator of bone resorption. J. Bone Miner. Res. 10, 1040–1049. <https://doi.org/10.1002/jbmr.5650100708>
31. Robert-Koch-Institut (2011) Beiträge zur Gesundheitsberichterstattung des Bundes. Daten und Fakten: Ergebnisse der Studie “Gesundheit in Deutschland aktuell”. Available at: http://www.gbe-bund.de
32. Seftel, A. D., Sun, P., Swindle, R. (2004) The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J. Urol. 171, 2341–2345. <https://doi.org/10.1097/01.ju.0000125198.32936.38>
33. Tamler, R., Deveney, T. (2010) Hypogonadism, erectile dysfunction, and type 2 diabetes mellitus: what the clinician needs to know. Postgrad. Med. 122, 165–175. <https://doi.org/10.3810/pgm.2010.11.2234>
34. Wimalawansa, S. J. (2007) Rationale for using nitric oxide donor therapy for prevention of bone loss and treatment of osteoporosis in humans. Ann. N. Y. Acad. Sci. 1117, 283–297. <https://doi.org/10.1196/annals.1402.066>
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