Prague Med. Rep. 2016, 117, 81-89

https://doi.org/10.14712/23362936.2016.8

Smoking Prevalence and Its Clinical Correlations in Patients with Narcolepsy-cataplexy

Pavla Peřinová1, Eva Feketeová2, David Kemlink1, Petra Kovalská1, Karolína Chlebušová1, Jiří Nepožitek1, Veronika Ibarburu1, Eva Králíková3,4, Soňa Nevšímalová1, Karel Šonka1

1Centre for Sleep and Wake Disorders, Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
2Department of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice and Louis Pasteur University Hospital, Košice, Slovak Republic
3Centre for Tobacco-Dependent, 3rd Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
4Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

Received January 15, 2016
Accepted September 2, 2016

Narcolepsy-cataplexy (NC) is a chronic neurological disease with suggested autoimmune etiopathogenesis. Nicotine stimulates central nervous system and smoking increases the risk of autoimmune diseases. Assessment of smoking habits and its correlation to clinical parameters among 87 adult NC patients (38 male, 49 female) included night polysomnography and multiple sleep latency test. In our sample, 43.7% NC patients were regular smokers, and 19.5% former smokers compared to 22.2%, and 12.6%, respectively, in the general population. Patients started to smoke in the mean age of 20.0 (SD ±6.0) years. 72.2% of NC smokers started to smoke before the onset of NC and the mean of the delay between smoking onset and NC onset was 9.1 (±5.8) years. We found a direct correlation between smoking duration and the number of awakenings, duration of N1 sleep, REM sleep latency, and apnoea/hypopnoea index (AHI), and, on the contrary, indirect correlation between smoking duration and N3 sleep duration, showing that smoking duration consistently correlates with sleep macrostructure. Smoking is highly prevalent in NC and has relationship with clinical features of NC.

Funding

This study was supported by a grant by the Ministry of Health of the Czech Republic, NF 13238-4/2012, and a grant by Charles University, PRVOUK P26/LF1/4.

References

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