Prague Med. Rep. 2017, 118, 105-109
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriate as most probably the valproic acid dose escalation would not be sufficient to achieve therapeutic serum concentration.
Funding
This study was supported by the Charles University Project Progress Q25 and a grant No. SVV 260373.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
