Prague Med. Rep. 2017, 118, 147-155

https://doi.org/10.14712/23362936.2017.16

Acquired Amegakaryocytic Thrombocytopenic Purpura Progressing into Aplastic Anemia

Jan Philipp Novotný, Birgit Köhler, Regina Max, Gerlinde Egerer

Department of Medicine V, University of Heidelberg, Heidelberg, Germany

Received August 10, 2017
Accepted December 5, 2017

References

1. Bulchandani, D., Nachnani, J., Belt, R., Hinton, S. (2007) Acquired pure megakaryocytic aplasia: Report of a single case treated with mycophenolate mofetil. Am. J. Hematol. 82, 650–651. <https://doi.org/10.1002/ajh.20895>
2. Cela, I., Miller, I. J., Katz, R. S., Rizman, A., Shammo, J. M. (2010) Successful treatment of amegakaryocytic thrombocytopenia with eltrombopag in a patient with systemic lupus erythematosus (SLE). Clin. Adv. Hematol. Oncol. 8, 806–809.
3. Chang, M., Nakagawa, P. A., Williams, S. A., Schwartz, M. R., Imfeld, K. L., Buzby, J. S., Nugent, D. J. (2003) Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 102, 887–895. <https://doi.org/10.1182/blood-2002-05-1475>
4. Cines, D. B., Bussel, J. B., Liebman, H. A., Luning Prak, E. T. (2009) The ITP syndrome: Pathogenic and clinical diversity. Blood 113, 6511–6521. <https://doi.org/10.1182/blood-2009-01-129155> <PubMed>
5. Deeren, D., Dorpe, J. V. (2010) Effective use of rituximab for acquired amegakaryocytic thrombocytopenia. Am. J. Hematol. 85, 977–978. <https://doi.org/10.1002/ajh.21882>
6. Doubek, M., Koristek, Z., Havranova, D., Smardova, L., Mayer, J. (2006) Megakaryocyte colony-forming unit growth is enhanced by alemtuzumab: in vitro experiments and a case report of acquired amegakaryocytic thrombocytopenic purpura. Leukemia 20, 1618–1619. <https://doi.org/10.1038/sj.leu.2404337>
7. Emmons, R. V., Reid, D. M., Cohen, R. L., Meng, G., Young, N. S., Dunbar, C. E., Shulman, N. R. (1996) Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87, 4068–4071.
8. Erkurt, M. A., Kaya, E., Baran, M., Yitmen, E., Senel, S., Kuku, I., Aydogdu, I. (2005) Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report. Turk. J. Haematol. 22, 205–208.
9. Ernestho-ghoud, I. M., Rahamefy, O., Ranaivo, I. M., Andrianarison, M., Ramarozatovo, L. S., Rabenja, F. R. (2015) Acquired amegakaryocytic thrombocytopenia purpura: think of systemic lupus erythematosus. Pan Afr. Med. J. 20, 86. (in French) <https://doi.org/10.11604/pamj.2015.20.86.5694> <PubMed>
10. Geissler, D., Thaler, J., Konwalinka, G., Peschel, C. (1987) Progressive preleukemia presenting amegakaryocytic thrombocytopenic purpura: Association of the 5q- syndrome with a decreased megakaryocytic colony formation and a defective production of Meg-CSF. Leuk. Res. 11, 731–737. <https://doi.org/10.1016/0145-2126(87)90010-5>
11. Gewirtz, A. M., Sacchetti, M. K., Bien, R., Barry, W. E. (1986) Cell-mediated suppression of megakaryocytopoiesis in acquired amegakaryocytic thrombocytopenic purpura. Blood 68, 619–626.
12. Hashimoto, A., Kanisawa, Y., Fujimi, A., Nakajima, C., Hayasaka, N., Yamada, S., Okuda, T., Minami, S., Yamauchi, N., Iwasaki, S., Suzuki, A., Kato, J. (2016) Thrombocytopenia and anemia with anti-c-Mpl antibodies effectively treated with cyclosporine in a patient with rheumatoid arthritis and chronic renal failure. Intern. Med. 55, 683–687. <https://doi.org/10.2169/internalmedicine.55.5190>
13. Hoffman, R., Bruno, E., Elwell, J., Mazur, E., Gewirtz, A. M., Dekker, P., Denes, A. E. (1982) Acquired amegakaryocytic thrombocytopenic purpura: a syndrome of diverse etiologies. Blood 60, 1173–1178.
14. Hoffman, R., Briddell, R. A., van Besien, K., Srour, E. F., Guscar, T., Hudson, N. W., Ganser, A. (1989) Acquired cyclic amegakaryocytic thrombocytopenia associated with an immunoglobulin blocking the action of granulocyte-macrophage colony-stimulating factor. N. Engl. J. Med. 321, 97–102. <https://doi.org/10.1056/NEJM198907133210207>
15. Katsumata, Y., Suzuki, T., Kuwana, M., Hattori, Y., Akizuki, S., Sugiura, H., Matsuoka, Y. (2003) Anti-c-Mpl (thrombopoietin receptor) autoantibody-induced amegakaryocytic thrombocytopenia in a patient with systemic sclerosis. Arthritis Rheum. 48, 1647–1651. <https://doi.org/10.1002/art.10965>
16. King, J. A., Elkhalifa, M. Y., Latour, L. F. (1997) Rapid progression of acquired amegakaryocytic thrombocytopenia to aplastic anemia. South. Med. J. 90, 91–94. <https://doi.org/10.1097/00007611-199701000-00024>
17. King, S., Germeshausen, M., Strauss, G., Welte, K., Ballmaier, M. (2004) Congenital amegakaryocytic thrombocytopenia (CAMT): A detailed clinical analysis of 21 cases reveals different types of CAMT. Blood 104, 740.
18. King, S., Germeshausen, M., Strauss, G., Welte, K., Ballmaier, M. (2005) Congenital amegakaryocytic thrombocytopenia: a retrospective clinical analysis of 20 patients. Br. J. Haematol. 131, 636–644. <https://doi.org/10.1111/j.1365-2141.2005.05819.x>
19. Leach, J. W., Hussein, K. K., George, J. N. (1999) Acquired pure megakaryocytic aplasia report of two cases with long-term responses to antithymocyte globulin and cyclosporine. Am. J. Hematol. 62, 115–117. <https://doi.org/10.1002/(SICI)1096-8652(199910)62:2<115::AID-AJH10>3.0.CO;2-2>
20. Lonial, S., Bilodeau, P. A., Langston, A. A., Lewis, C., Mossavi-Sai, S., Holden, J. T., Waller, E. K. (1999) Acquired amegakaryocytic thrombocytopenia treated with allogeneic BMT: a case report and review of the literature. Bone Marrow Transplant. 24, 1337–1341. <https://doi.org/10.1038/sj.bmt.1702063>
21. Lown, R., Rhodes, E., Bosworth, J., Shannon, M. S., Stasi, R. (2010) Acquired amegakaryocytic thrombocytopenia: potential role of thrombopoietin receptor agonists. Clin. Adv. Hematol. Oncol. 8, 809–812.
22. Lugassy, G. (1996) Non-Hodgkin’s lymphoma presenting with amegakaryocytic thrombocytopenic purpura. Ann. Hematol. 73, 41–42. <https://doi.org/10.1007/s002770050199>
23. McMillan, R., Wang, L., Tomer, A., Nichol, J., Pistillo, J. (2004) Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 103, 1364–1369. <https://doi.org/10.1182/blood-2003-08-2672>
24. Meytes, D., Levi, M., Virag, I., Fried, D. (1984) Acquired amegakaryocytic thrombocytopenia with rapid progression into aplastic anemia. Harefuah 106, 509–510. (in Hebrew)
25. Mirzania, M., Khalili, S., Hasanpoor, A., Shamshiri, A. R. (2014) Anti-CD20 antibody is effective in the patient with refractory amegakaryocytic thrombocytopenia, 25 months follow up. Int. J. Hematol. Oncol. Stem Cell Res. 8, 41–44.
26. Niparuck, P., Atichartakarn, V., Chuncharunee, S. (2008) Successful treatment of acquired amegakaryocytic thrombocytopenic purpura refractory to corticosteroids and intravenous immunoglobulin with antithymocyte globulin and cyclosporine. Int. J. Hematol. 88, 223–226. <https://doi.org/10.1007/s12185-008-0125-0>
27. Olsson, B., Andersson, P. O., Jernas, M., Jacobsson, S., Carlsson, B., Carlsson, L. M., Wadenvik, H. (2003) T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat. Med. 9, 1123–1124. <https://doi.org/10.1038/nm921>
28. Omri, H. E., Ibrahim, F., Taha, R. Y., Negm, R. H., Khinji, A. A., Yassin, M., Hijji, I. A., Ayoubi, H. E., Baden, H. (2010) Acquired pure megakaryocytic aplasia successfully treated with cyclosporine. Turk. J. Haematol. 27, 289–293. <https://doi.org/10.5152/tjh.2010.51>
29. Sakurai, T., Kono, I., Kabashima, T., Yamane, K., Nagasawa, T., Kashiwagi, H. (1984) Amegakaryocytic thrombocytopenia associated with systemic lupus erythematosus successfully treated by a high-dose prednisolone therapy. Jpn. J. Med. 23, 135–138. <https://doi.org/10.2169/internalmedicine1962.23.135>
30. Shigekiyo, T., Sekimoto, E., Shibata, H., Ozaki, S., Fujinaga, H., Hirose, T. (2015) Treatment of acquired amegakaryocytic thrombocytopenic purpura with romiplostim. Platelets 26, 504–506. <https://doi.org/10.3109/09537104.2014.913128>
front cover

ISSN 1214-6994 (Print) ISSN 2336-2936 (Online)

Archive