Prague Med. Rep. 2019, 120, 10-17

https://doi.org/10.14712/23362936.2019.6

Is Cardiometabolic Index a Predictive Marker for Renal Cell Cancer Aggressiveness?

Murat Dursun1, Huseyin Besiroglu2, Alper Otunctemur3, Emin Ozbek4

1Department of Urology, Malatya Training and Research Hospital, Malatya, Turkey
2Department of Urology, Catalca Ilyas Cokay State Hospital, Istanbul, Turkey
3Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey
4Department of Urology, Istanbul Cerrahpasa Medical Faculty, Istanbul, Turkey

Received October 17, 2018
Accepted May 2, 2019

Studies show that metabolic syndrome is a factor for developing renal cell cancer (RCC) and tumour aggressiveness. In our study, we evaluated the association between renal cell cancer and cardiometabolic index (CMI) which meets the main components of the metabolic syndrome. We retrospectively reviewed the records of 310 consecutive patients with RCC who underwent radical nephrectomy at our institution. We evaluated the tumour size, histologic subtype, Fuhrman nuclear grade. CMI was calculated as the product of waist circumference (WC) to waist-to-height ratio (WHtR) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c). CMI were statistically higher in patients with tumour size ≥ 7 cm than those < 7 cm (p<0.05). Mean CMI level was 2.34 ± 0.84 in patients with high tumour size; and 1.18 ± 0.74 in the other group. The patients with high tumour size had higher TG levels, higher WC and lower HDL-c levels. Similarly, CMI levels were statistically higher in patients with Fuhrman grade 3 and 4 than patients with Fuhrman grade 1 and 2 (p<0.001). The patients with high Fuhrman grade had higher TG levels, higher WC and lower HDL-c levels. The simplicity of WC and height measurement and TG and HDL assessment make CMI an easily applicable index for the evaluation of cardiovascular dysfunction. The components of CMI may have effect on tumour carcinogenesis in similar pathways. In this context, CMI which meets the main components of the metabolic syndrome, can be a useful index for the evaluation and calculation of renal cell cancer aggressiveness.

References

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