Prague Med. Rep. 2020, 121, 244-253

https://doi.org/10.14712/23362936.2020.21

Post-mortem Redistribution of Alprazolam in Rats

Jana Hořínková1, Petr Kozlík2, Tomáš Křížek2, Danica Michaličková1, Martin Šíma1, Ondřej Slanař1

1Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
2Department of Analytical Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

Received March 7, 2020
Accepted November 2, 2020

References

1. Banks, W. R., Yamakita, H., Digenis, G. A. (1992) Metabolism and distribution of 1-[14C]alprazolam in rats. J. Pharm. Sci. 81, 797–801. <https://doi.org/10.1002/jps.2600810815>
2. Boyd, E. M., Knight, L. M. (1963) Postmortem shifts in the weight and water levels of body organs. Toxicol. Appl. Pharmacol. 5, 119–128. <https://doi.org/10.1016/0041-008X(63)90086-3>
3. Castaing, N., Titier, K., Canal-Raffin, M., Moore, N., Molimard, M. (2006) Postmortem redistribution of two antipsychotic drugs, haloperidol and thioridazine, in the rat. J. Anal. Toxicol. 30, 419–425. <https://doi.org/10.1093/jat/30.7.419>
4. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2019) European Drug Report: Trends and Developments. Available at: http://www.emcdda.europa.eu/system/files/publications /11364/20191724_TDAT19001ENN_PDF.pdf
5. Greenblatt, D. J., Wright, C. E. (1993) Clinical pharmacokinetics of alprazolam. Therapeutic implications. Clin. Pharmacokinet. 24, 453–471.
6. Han, E., Kim, E., Hong, H., Jeong, S., Kim, J., In, S., Chung, H., Lee, S. (2012) Evaluation of postmortem redistribution phenomena for commonly encountered drugs. Forensic Sci. Int. 219, 265–271. <https://doi.org/10.1016/j.forsciint.2012.01.016>
7. Hargrove, V. M., McCutcheon, J. R. (2008) Comparison of drug concentrations taken from clamped and unclamped femoral vessels. J. Anal. Toxicol. 32, 621–625. <https://doi.org/10.1093/jat/32.8.621>
8. Hilberg, T., Ripel, A., Slordal, L., Bjorneboe, A., Morland, J. (1999) The extent of postmortem drug redistribution in a rat model. J. Forensic Sci. 44, 956–962.
9. Isbister, G. K., O’Regan, L., Sibbritt, D., Whyte, I. M. (2004) Alprazolam is relatively more toxic than other benzodiazepines in overdose. Br. J. Clin. Pharmacol. 58, 88–95. <https://doi.org/10.1111/j.1365-2125.2004.02089.x>
10. Jenkins, A. J., Levine, B., Locke, J. L., Smialek, J. E. (1997) A fatality due to alprazolam intoxication. J. Anal. Toxicol. 21, 218–220. <https://doi.org/10.1093/jat/21.3.218>
11. Jones, A. W., Holmgren, A., Ahlner, J. (2016) Post-mortem concentrations of drugs determined in femoral blood in single-drug fatalities compared with multi-drug poisoning deaths. Forensic Sci. Int. 267, 96–103. <https://doi.org/10.1016/j.forsciint.2016.08.015>
12. Jonsson, A., Holmgren, P., Ahlner, J. (2004) Fatal intoxications in a Swedish forensic autopsy material during 1992–2002. Forensic Sci. Int. 143, 53–59. <https://doi.org/10.1016/j.forsciint.2004.02.010>
13. Koren, G., MacLeod, S. M. (1985) Postmortem redistribution of digoxin in rats. J. Forensic Sci. 30, 92–96. <https://doi.org/10.1520/JFS10968J>
14. Koren, G., Klein, J. (1992) Postmortem redistribution of morphine in rats. Ther. Drug Monit. 14, 461–463.
15. Kposowa, A. J., McElvain, J. P. (2006) Gender, place, and method of suicide. Soc. Psychiatry Psychiatr. Epidemiol. 41, 435–443. <https://doi.org/10.1007/s00127-006-0054-2>
16. Kugelberg, F. C., Druid, H., Carlsson, B., Ahlner, J., Bengtsson, F. (2004) Postmortem redistribution of the enantiomers of citalopram and its metabolites: an experimental study in rats. J. Anal. Toxicol. 28, 631–637. <https://doi.org/10.1093/jat/28.8.631>
17. McIntyre, I. M., Gary, R. D., Joseph, S., Stabley, R. (2017) A fatality related to the synthetic opioid U-47700: Postmortem concentration distribution. J. Anal. Toxicol. 41, 158–160.
18. Musther, H., Olivares-Morales, A., Hatley, O. J., Liu, B., Rostami Hodjegan, A. (2014) Animal versus human oral drug bioavailability: do they correlate? Eur. J. Pharm. Sci. 57, 280–291. <https://doi.org/10.1016/j.ejps.2013.08.018>
19. Nair, A. B., Jacob, S. (2016) A simple practice guide for dose conversion between animals and human. J. Basic Clin. Pharm. 7, 27–31. <https://doi.org/10.4103/0976-0105.177703>
20. Pounder, D. J., Fuke, C., Cox, D. E., Smith, D., Kuroda, N. (1996) Postmortem diffusion of drugs from gastric residue: an experimental study. Am. J. Forensic Med. Pathol. 17, 1–7. <https://doi.org/10.1097/00000433-199603000-00001>
21. Shiota, H., Nakashima, M., Terazono, H., Sasaki, H., Nishida, K., Nakamura, J., Taniyama, K. (2004) Postmortem changes in tissue concentrations of triazolam and diazepam in rats. Leg. Med. (Tokyo) 6, 224–232. <https://doi.org/10.1016/j.legalmed.2004.05.006>
22. U. S. Food and Drug Administration; Department of Health and Human Services (2015) Analytical Procedures and Methods Validation for Drugs and Biologics: Guidance for Industry. Available at: https://www.fda.gov /files/drugs/published/Analytical-Procedures-and-Methods-Validation-for-Drugs-and-Biologics.pdf
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