Prague Med. Rep. 2021, 122, 45-51

https://doi.org/10.14712/23362936.2021.6

Obstructive Jaundice Secondary to Pancreatic Head Metastasis of Malignant Amelanotic Melanoma as the First Clinical Manifestation

Jan Zeman1, Lucie Olivová2, Jan Hrudka3, Jan Hajer4, Ivan Rychlík1

1Department of Internal Medicine, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
2Department of Dermatology, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
3Department of Pathology, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic
4Department of Gastroenterology, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic

Received June 25, 2020
Accepted January 28, 2021

Malignant melanoma is commonly known for its high probability of metastasizing to distant organs. Metastases to gastrointestinal tract are well documented, but resulting jaundice is only scarcely seen. We present a case of histologically verified metastasis of amelanotic melanoma to the head of pancreas infiltrating the common bile duct and consequently causing obstructive jaundice which constituted its first clinical manifestation. Multidisciplinary approach is essential in patients with malignant melanoma since early detection of the melanoma or its metastases may improve patients’ clinical outcome, especially owing to the use of targeted biological treatment without any delay.

Funding

This study was supported by the research program Charles University PROGRES Q28 – Oncology.

References

21 live references