Prague Med. Rep. 2022, 123, 225-242

https://doi.org/10.14712/23362936.2022.21

A Response of the Pineal Gland in Sexually Mature Rats under Long-term Exposure to Heavy Metal Salts

Nataliia Hryntsova1, Ingrid Hodorová2, Josef Mikhaylik2, Anatoly Romanyuk3

1Department of Morphology, Medical Institute, Sumy State University, Sumy, Ukraine
2Department of Anatomy, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic
3Department of Pathological Anatomy, Medical Institute, Sumy State University, Sumy, Ukraine

Received December 11, 2020
Accepted November 2, 2022

References

1. Apikhtina, O. L., Dmitrukha, N. M., Kotsyuruba, A. I. (2012) The mechanism of hemotoxic action of lead. J. National Acad. Med. Sci. Ukr. 18(1), 100–109. (in Ukraine)
2. Arushanyan, E. B. (2004) Antistress Potential of Epiphyseal Melatonin. Melatonin in Health and Disease. Nauka, Moscow. (in Russian)
3. Arushanyan, E. B., Elbekyan, K. S. (2006) Immunotoxicity of metal salts and the protective role of epiphyseal factors. Biomed. Chem. 52(6), 547–555. (in Russian)
4. Belenichev, I. F. (2014) Neuroprotection and Neuroplasticity. Polygraph plus, Kiev. (in Ukraine)
5. Bharti, V. K., Srivastava, R. S., Kumar, H., Bag, S., Majumdar, A. C., Singh, G., Pandi-Perumal, S. R., Brown, G. M. (2014) Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats. Adv. Pharmacol. Sci. 2014, 532969.
6. Bondarenko, A. A., Gubina-Vakulik, G. I., Gevorgyan, A. R. (2013) Pineal gland and hypothalamic-pituitary-thyroid system: Age and chronobiological aspects. Institute Endocrinol. Pathol., Kharkiv. (in Ukraine)
7. Daniels, W. M., van Rensburg, S. J., van Zyl, J. M., Taljaard, J. J. (1998) Melatonin prevents beta-amyloid-induced lipid peroxidation. J. Pineal Res. 24, 78–82. <https://doi.org/10.1111/j.1600-079X.1998.tb00370.x>
8. Drozdova, G. A., Samigullina, A. F., Nurgaleeva, E. A. (2017) Posthypoxic reaction of astroglial cells of the visual cortex in the experiment. Kazan Med. Zh. 98(6), 984–988. (in Russian) <https://doi.org/10.17750/KMJ2017-984>
9. El-Missiry, M. A. (2000) Prophylactic effect of melatonin on lead-induced inhibition of heme biosynthesis and deterioration of antioxidant systems in male rats. J. Biochem. Mol. Toxicol. 14, 57–62. <https://doi.org/10.1002/(SICI)1099-0461(2000)14:1<57::AID-JBT8>3.0.CO;2-B>
10. El-Sokkary, G. H., Kamel, E. S., Reiter, R. J. (2003) Prophylactic effect of melatonin in reducing lead-induced neurotoxicity in the rat. Cell. Mol. Biol. Lett. 8, 461–470.
11. Goryainov, S. A., Protskiy, S. V., Okhotin, V. E. (2013) On the role of astroglia in the brain in health and disease. Annals Clin. Experiment. Neurol. 7(1), 45–51.
12. Gubina-Vakulik, G. I. (2006) An attempt to generalize the results of a histopathological examination of the epiphysis of the brain. Bukov. Med. Visnik. 10(4), 34–36.
13. Hemdan, N. Y., Emmrich, F., Adham, K., Wichmann, G., Lehmann, I., El-Massry, A., Ghoneim, H., Lehmann, J., Sack, U. (2005) Dose-dependent modulation of the in vitro cytokine production of human immune competent cells by lead salts. Toxicol. Sci. 86, 75–83. <https://doi.org/10.1093/toxsci/kfi177>
14. Hryntsova, N. B., Romanyuk, A. M. (2020) Method of identification and atraumatic extraction of pineal gland in rats. Utility model patent No. 142276/25.05.20 of the State Register of utility model patents of Ukraine.
15. Hryntsova, N. B., Romanyuk, A. M., Lindin, M. S., Lindina, Y. M. (2020) Modified method of preparation of histological preparations of the pineal gland of rats. Patent for utility model No. 142314/25.05.20 of the State Register of Patents of Ukraine for utility models.
16. Hryntsova, N. B., Romanyuk, A. M., Zaitseva, S. S., Gordienko, O. V., Khomenko, I. V., Kiptenko, L. I. (2022) Effect of L-tocopherol on morphological reformations of rat pineal gland under the impact of heavy metal salts. World Med. Biol. 1(79), 184–188. <https://doi.org/10.26724/2079-8334-2022-1-79-184-188>
17. Karbownik, M., Lewinski, A. (2003) Melatonin reduces Fenton reaction-induced lipid peroxidation in porcine thyroid tissue. J. Cell. Biochem. 90(4), 806–811. <https://doi.org/10.1002/jcb.10689>
18. Köhrle, J., Jakob, F., Contempré, B., Dumont, J. E. (2005) Selenium, the thyroid, and the endocrine system. Endocr. Rev. 26, 944–984. <https://doi.org/10.1210/er.2001-0034>
19. Kravtsiv, R. Y., Yanovich, D. O. (2008) The role of selenium in the functioning of the endocrine system, organs and tissues of animals. Biol. Anim. 10(1–2), 33–48. (in Ukraine)
20. Limson, J., Nyokong, T., Daya, S. (1998) The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: An adsorptive voltammetric study. J. Pineal Res. 24, 15–21. <https://doi.org/10.1111/j.1600-079X.1998.tb00361.x>
21. Lutsik, S. O., Yashchenko, A. M. (2018) Immunohistochemical study of the adrenal glands of the offspring of rats that developed under the conditions of experimental hypo- and hyperthyroidism of the maternal organism. World Med. Biol. 4(66), 175–180. <https://doi.org/10.26724/2079-8334-2018-4-66-175-180>
22. Razygraev, A. V. (2004) Activity of glutathione peroxidase in the tissue of the pineal gland of rats and its change during aging. Adv. Gerontol. 4, 19–22.
23. Reiter, R. J. (1996) Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals. Eur. J. Endocrinol. 134, 412–420. <https://doi.org/10.1530/eje.0.1340412>
24. Romanjuk, A., Lyndin, M., Lyndina, Y., Sikora, V., Hrintsova, N., Timakova, O., Gudymenko, O., Gladchenko, O. (2018a) Changes in the hematopoietic system and blood under the influence of heavy metal salts can be reduced with vitamin E. Turk Patoloji Derg. 34, 73–81.
25. Romanjuk, A., Hryntsova, N., Romanjuk, O., Lyndin, M., Karpenko, L. (2018b) Morphological and immune histochemical alterations of astrocyte neuroglia of epiphysis under conditions of long-term influence of heavy metals salts on the organism. 30th European Congress of Pathology, 8–12 September 2018, Bilbao, Spain. Virchows Archiv (Eur. J. Pathol.) 473, 27 (Suppl. 1).
26. Romanjuk, A., Hryntsova, N., Karpenko, L. (2019) The long-term effect of the complex of heavy metal salts on the morphofunctional changes in the structural components of the intermediate lobe of the mature rat’s pituitary gland – The female. Problems Endocrinol. Pathol. 2, 98–103. <https://doi.org/10.21856/j-PEP.2019.2.14>
27. Rusetskaya, N. Y., Borodulin, V. B. (2015) Biological activity of selenorganic compounds at heavy metal salts intoxication. Biomed. Khim. 61(4), 449–461. (in Russian) <https://doi.org/10.18097/PBMC20156104449>
28. Russel, J. (2000) Melatonin: Lowering the high price of free radicals. News Physiol. Sci. 15, 246–250.
29. Rzeuski, R., Chlubek, D., Machoy, Z. (1998) Interactions between fluoride and biological free radical reactions. Fluoride 31(1), 43–45.
30. Salkov, V. N., Khudoerkov, R. M., Voronkov, D. N., Noss, N. S. (2015) Morphological parameters of the heterogeneity of the substantia nigra in elderly men and women. Arkh. Patol. 77(4), 51–54. (in Russian) <https://doi.org/10.17116/patol201577451-54>
31. Shafran, L. M., Bolshoi, D. V., Pykhteeva, E. G., Tretyakova, E. M. (2004) The role of lysosomes in the mechanism of protection and cell damage under the action of heavy metals. Modern Problems Toxicol. 3, 52–56.
32. Shahid, M., Pourrut, B., Dumat, C., Nadeem, M., Aslam, M., Pinelli, E. (2014) Heavy-metal-induced reactive oxygen species: Phytotoxicity and physicochemical changes in plants. Rev. Environ. Contam. Toxicol. 232, 1–44.
33. Shkorbatov, Y. G. (2005) Structural and electrochemical power of the nuclei of the civil society of people with the sound of physical and chemical factors and the great functionality of the body. MDS Thesis, Kiev State University.
34. Susa, N., Ueno, S., Furukawa, Y., Ueda, M., Sugiyama, M. (1997) Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol., 144, 377–384. <https://doi.org/10.1006/taap.1997.8151>
35. Trachtenberg, I. M., Korolenko, T. K., Utko, N. A., Muradyan, H. K. (2001) Lead and oxidative stress. Probl. Modern Toxicol. 4, 28–36.
36. Trachtenberg, I. M., Lubyanova, I. P., Apykhtina, E. L. (2010) The role of lead and iron as man-made chemical pollutants in the pathogenesis of cardiovascular diseases. Ukr. Med. Bull. 7–8, 36–39.
37. Trachtenberg, I. M., Dmitrukha, N. M., Lugovsky, S. P. (2015) Lead is a dangerous pollutant. The problem is old and new. Modern Probl. Toxicol. Food Chemical Safety 3, 14–24.
38. Valko, M., Morris, H., Cronin, M. T. (2005) Metals, toxicity and oxidative stress. Curr. Med. Chem. 12, 1161–1208. <https://doi.org/10.2174/0929867053764635>
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