Prague Med. Rep. 2023, 124, 166-171

Sperm DNA Fragmentation Index in Abortion or in Vitro Fertilization Failure in Presence of Normal Semen Analysis

Hamed Akhavizadegan1, Nazila Yamini2, Amir Masoud Musavi3, Maryam Moradi2, Farnaz Khatami3

1Department of Urology, Tehran University of Medical Sciences, Tehran, Iran
2Arash Infertility Center, Tehran University of Medical Sciences, Tehran, Iran
3School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Received April 18, 2021
Accepted April 24, 2023


1. Cho, C. L., Agarwal, A., Majzoub, A., Esteves, S. C. (2017) Future direction in sperm DNA fragmentation testing. Transl. Androl. Urol. 6, S525–S526 (Suppl. 4). <>
2. ESHRE Guideline Group on RPL; Bender Atik, R., Christiansen, O. B., Elson, J., Kolte, A. M., Lewis, S., Middeldorp, S., Nelen, W., Peramo, B., Quenby, S., Vermeulen, N., Goddijn, M. (2018) ESHRE guideline: Recurrent pregnancy loss. Hum. Reprod. Open 2018(2), hoy004. <>
3. Gunes, S., Hekim, G. N., Arslan, M. A., Asci, R. (2016) Effects of aging on the male reproductive system. J. Assist. Reprod. Genet. 33(4), 441–454. <>
4. Humm, K. C., Sakkas, D. (2013) Role of increased male age in IVF and egg donation: Is sperm DNA fragmentation responsible? Fertil. Steril. 99(1), 30–36. <>
5. McQueen, D. B., Zhang, J., Robins, J. C. (2019) Sperm DNA fragmentation and recurrent pregnancy loss: A systematic review and meta-analysis. Fertil. Steril. 112(1), 54–60.e3. <>
6. Petersen, C. G., Mauri, A. L., Vagnini, L. D., Renzi, A., Petersen, B., Mattila, M., Comar, V., Ricci, J., Dieamant, F., Oliveira, J. B. A., Baruffi, R. L. R., Franco, J. G. Jr. (2018) The effects of male age on sperm DNA damage: An evaluation of 2,178 semen samples. JBRA Assist. Reprod. 22(4), 323–330.
7. Pino, V., Sanz, A., Valdés, N., Crosby, J., Mackenna, A. (2020) The effects of aging on semen parameters and sperm DNA fragmentation. JBRA Assist. Reprod. 24(1), 82–86.
8. Santi, D., Spaggiari, G., Simoni, M. (2018) Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management – meta-analyses. Reprod. Biomed. Online 37(3), 315–326. <>
9. Shaulov, T., Sierra, S., Sylvestre, C. (2020) Recurrent implantation failure in IVF: A Canadian Fertility and Andrology Society Clinical Practice Guideline. Reprod. Biomed. Online 41(5), 819–833. <>
10. Tan, J., Taskin, O., Albert, A., Bedaiwy, M. A. (2019) Association between sperm DNA fragmentation and idiopathic recurrent pregnancy loss: A systematic review and meta-analysis. Reprod. Biomed. Online 38(6), 951–960. <>
11. Wiweko, B., Utami, P. (2017) Predictive value of sperm deoxyribonucleic acid (DNA) fragmentation index in male infertility. Basic Clin. Androl. 27, 1. <>
12. Yifu, P., Lei, Y., Shaoming, L., Yujin, G., Xingwang, Z. (2020) Sperm DNA fragmentation index with unexplained recurrent spontaneous abortion: A systematic review and meta-analysis. J. Gynecol. Obstet. Hum. Reprod. 49, 101740. <>
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ISSN 1214-6994 (Print) ISSN 2336-2936 (Online)