Prague Med. Rep. 2023, 124, 172-176

Side Effects of Antihypertensives Induced by Switching to Different Generic Medications: Case Reports

Apichai Wattanapisit1,2, Penpun Lertwatanachai1,2, Thittita Pongsawat2, Sanhapan Wattanapisit3, Jaruporn Thongruch2

1School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand
2Walailak University Hospital, Nakhon Si Thammarat, Thailand
3Thasala Hospital, Nakhon Si Thammarat, Thailand

Received December 2, 2022
Accepted April 18, 2023


1. Desai, R. J., Sarpatwari, A., Dejene, S., Khan, N. F., Lii, J., Rogers, J. R., Dutcher, S. K., Raofi, S., Bohn, J., Connolly, J. G., Fischer, M. A., Kesselheim, A. S., Gagne, J. J. (2019) Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims. PLoS Med. 16(3), e1002763. <>
2. Edwards, I. R., Aronson, J. K. (2000) Adverse drug reactions: Definitions, diagnosis, and management. Lancet 356(9237), 1255–1259. <>
3. Gallelli, L., Gallelli, G., Codamo, G., Argentieri, A., Michniewicz, A., Siniscalchi, A., Stefanelli, R., Cione, E., Caroleo, M. C., Longo, P., De Sarro, G. (2016) Recognizing severe adverse drug reactions: Two case reports after switching therapies to the same generic company. Curr. Drug Saf. 11(1), 104–108. <>
4. Gibson, G. R. (1989) Enalapril-induced cough. Arch. Intern. Med. 149(12), 2701–2703. <>
5. Insani, W. N., Whittlesea, C., Alwafi, H., Man, K. K. C., Chapman, S., Wei, L. (2021) Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis. PLoS One 16(5), e0252161. <>
6. Ionova, Y., Wilson, L. (2020) Biologic excipients: Importance of clinical awareness of inactive ingredients. PLoS One 15(6), e0235076. <>
7. Lemay, J., Waheedi, M., Al-Sharqawi, S., Bayoud, T. (2018) Medication adherence in chronic illness: Do beliefs about medications play a role? Patient Prefer. Adherence 12, 1687–1698. <>
8. Pottel, J., Armstrong, D., Zou, L., Fekete, A., Huang, X.-P., Torosyan, H., Bednarczyk, D., Whitebread, S., Bhhatarai, B., Liang, G., Jin, H., Ghaemi, S. N., Slocum, S., Lukacs, K. V., Irwin, J. J., Berg, E. L., Giacomini, K. M., Roth, B. L., Shoichet, B. K., Urban, L. (2020) The activities of drug inactive ingredients on biological targets. Science 369(6502), 403–413. <>
9. Reker, D., Blum, S. M., Steiger, C., Anger, K. E., Sommer, J. M., Fanikos, J., Traverso, G. (2019) “Inactive” ingredients in oral medications. Sci. Transl. Med. 11(483), eaau6753. <>
10. Sellappans, R., Lai, P. S., Ng, C. J. (2015) Challenges faced by primary care physicians when prescribing for patients with chronic diseases in a teaching hospital in Malaysia: A qualitative study. BMJ Open 5(8), e007817. <>
11. Smith, W. (2013) Adverse drug reactions – Allergy? Side-effect? Intolerance? Aust. Fam. Physician 42(1–2), 12–16.
12. Yajnik, V. H., Vatsaraj, D. J., Acharya, H. K., Yajnik, N. V. (1995) Evaluation of amlodipine in mild to moderate hypertension – A clinical report. J. Assoc. Physicians India 43(1), 34–35.
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ISSN 1214-6994 (Print) ISSN 2336-2936 (Online)