Prague Med. Rep. 2023, 124, 230-241
Effect of Convalescent Plasma Therapy on Mortality and Viral Load in Severely Ill Patients with COVID-19
The use of convalescent plasma (CP) appeared to be a promising, easily available and safe way of treatment of severe COVID-19 at the onset of the pandemic in early 2020. Conducted in 2020 and 2021, our study of 52 severely to critically ill COVID-19 patients who received CP plasma as a treatment and of 97 controls found no difference in 30-day or 90-day mortality rates. A significant viral load drop in most patients (4.7 log10 [p<0.001] copies/ml) was observed following CP administration. Retrospective analysis of selected inflammatory markers and immunoglobulins showed higher C-reactive protein levels among the study group, and their decrease on Day 7.
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Funding
This study was supported by the Ministry of Health of the Czech Republic, grant no. NU22-A-123, and by MH CZ – DRO (Thomayer University Hospital – TUH, 00064190).
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Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
