Prague Med. Rep. 2025, 126, 75-81
https://doi.org/10.14712/23362936.2025.12
Correlation of Ki-67 Expression with the Stage of Disease in Patients of Colorectal Carcinoma
Ashutosh Nagpal
, Poras Chaudhary
, Poras Chaudhary
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India
Received February 1, 2024
Accepted May 12, 2025
References
1. , M. F., Soliman, M. M., Ahmed, M. F., Hassanin, T. M., Al Jehani, R. M., Mohamed, F. E. (2021) Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome. Pol. J. Pathol. 72(1), 39–47.
<https://doi.org/10.5114/pjp.2021.106442>
2. , S., Jung, J., Mezei, T., Pávai, Z. (2007) The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas. Rom. J. Morphol. Embryol. 48(2), 95–99.
3. , H., Miwa, H., Tatsuta, M., Masutani, S., Imamura, H., Shimizu, J., Ezumi, K., Kato, H., Kawasaki, T., Furukawa, H., Kawakami, H. (2004) Ki-67 and CEA expression as prognostic markers in Dukes’ C colorectal cancer. Cancer Lett. 207(1), 109–115.
<https://doi.org/10.1016/j.canlet.2003.10.032>
4. Kumar, V., Abbas, A. K., Aster, J. C. (2015) Neoplasia. In: Robbins and Cotran Pathologic Basis of Disease, 9th Edition. pp. 265–340, Elsevier Inc., Philadelphia.
5. , J., Liu, Z. Y., Yu, H. B., Qu, X. S., Xue, Q., Yu, H. T., Weeks, C. (2020) The association between Ki-67 expression and the clinical pathological characteristics of colorectal cancer: A protocol for a systematic review and meta-analysis. Medicine (Baltimore) 99(21), e19996.
<https://doi.org/10.1097/MD.0000000000019996>
6. , P., Xiao, Z.-T., Braciak, T. A., Ou, Q.-J., Chen, G., Oduncu, F. S. (2016) Association between Ki67 index and clinicopathological features in colorectal cancer. Oncol. Res. Treat. 39(11), 696–702.
<https://doi.org/10.1159/000450623>
7. , M.-X., Wen, Z.-F., Feng, Z.-Y., He, D. (2008) Expression and significance of Bmi-1 and Ki67 in colorectal carcinoma tissues. Ai Zheng 27(12), 1321–1326. (in Chinese)
8. , Y.-L., Peng, J.-Y., Zhang, P., Liu, W.-J., Huang, L., Qin, H.-L. (2010) Immunohistochemical analysis revealed CD34 and Ki67 protein expression as significant prognostic factors in colorectal cancer. Med. Oncol. 27(2), 304–309.
<https://doi.org/10.1007/s12032-009-9210-3>
9. , S. F., Amorim, R., Mota, S. C., Costa, L., Pardal, F., Rodrigues, M., Longatto-Filho, A. (2015) Ki-67 expression in CRC lymph node metastasis does not predict survival. Biomed Res. Int. 2015, 131685.
10. , N., Kowitz, C. M., Simon, R., Bokemeyer, C., Terracciano, L., Sauter, G., Izbicki, J. R., Marx, A. H. (2016) High Ki67 expression is an independent good prognostic marker in colorectal cancer. J. Clin. Pathol. 69(3), 209–214.
<https://doi.org/10.1136/jclinpath-2015-202985>
11. , F. L., Ali, H. H., Hussein, H. G., Al-Ukashi, R. J. (2011) Immunohistochemical expression of ki-67 and p53 in colorectal adenomas: A clinicopathological study. Oman Med. J. 26(4), 229–234.
<https://doi.org/10.5001/omj.2011.57>
12. , H. A., Jackson, H., Banerjee, M. (2000) Immunohistochemical expression of bcl-2 and p53 oncoproteins: Correlation with Ki67 proliferation index and prognostic histopathologic parameters in colorectal neoplasia. Appl. Immunohistochem. Mol. Morphol. 8(3), 175–182.
13. , C., Duchrow, M., Wohlenberg, C., Becker, M. H., Key, G., Flad, H. D., Gerdes, J. (1993) The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123(3), 513–522.
<https://doi.org/10.1083/jcb.123.3.513>
14. , T., Gerdes, J. (2000) The Ki-67 protein: From the known and the unknown. J. Cell. Physiol. 182(3), 311–322.
<https://doi.org/10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9>
15. , C. D., Tsamandas, A. C., Zolota, V., Kalofonos, H. P., Batistatou, A., Vagianos, C. (2003) Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: A clinicopathologic study. Dig. Dis. Sci. 48(10), 1990–1997.
<https://doi.org/10.1023/A:1026178506348>
16. , I. K., Jakic-Razumovic, J. (2014) The value of immunohistochemical determination of topoisomerase IIα and Ki67 as markers of cell proliferation and malignant transformation in colonic mucosa. Appl. Immunohistochem. Mol. Morphol. 22(7), 524–529.
<https://doi.org/10.1097/PAI.0b013e3182a1c9c6>
17. , H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., Bray, F. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249.
<https://doi.org/10.3322/caac.21660>
18. , H., Dhar, D. K., Nakamoto, T., Kotoh, T., Takano, M., Soma, G.-I., Nagasue, N. (2003) Prognostic significance of tumor necrosis factor receptor in colorectal adenocarcinoma. Anticancer Res. 23(1A), 85–89.
