Prague Med. Rep. 2025, 126, 159-161

https://doi.org/10.14712/23362936.2025.25

Unveiling the Enigma: Plasma Cell Leukaemia Presenting with Flower-like Cells, Mimicking Adult T-cell Leukaemia – A Rare Diagnostic Conundrum

Anurag Singh1ID, Gyanendra Singh2ID

1 Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
2 Department of Pathology, All India Institute of Medical Sciences, Rajkot, Gujarat, India

Received May 8, 2024
Accepted August 27, 2025

References

1. Dahmoush, L., Hijazi, Y., Barnes, E., Stetler-Stevenson, M., Abati, A. (2002) Adult T-cell leukemia/lymphoma: A cytopathologic, immunocytochemical, and flow cytometric study. Cancer 96(2), 110–116. <https://doi.org/10.1002/cncr.10480>
2. De Miguel Sánchez, C., Robles de Castro, D., Pisón Herrero, C., Pérez Persona, E., Salcedo Cuesta, L., Guinea de Castro, J. M. (2021) Primary plasma cell leukaemia presenting with flower-shaped nuclei. Br. J. Haematol. 193(4), 689. <https://doi.org/10.1111/bjh.17320>
3. Flores-Montero, J., de Tute, R., Paiva, B., Perez, J. J., Böttcher, S., Wind, H., Sanoja, L., Puig, N., Lecrevisse, Q., Vidriales, M. B., van Dongen, J. J., Orfao, A. (2016) Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma. Cytometry B Clin. Cytom. 90(1), 61–72. <https://doi.org/10.1002/cyto.b.21265>
4. García-Sanz, R., Orfão, A., González, M., Tabernero, M. D., Bladé, J., Moro, M. J., Fernández-Calvo, J., Sanz, M. A., Pérez-Simón, J. A., Rasillo, A., Miguel, J. F. (1999) Primary plasma cell leukemia: Clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 93(3), 1032–1037. <https://doi.org/10.1182/blood.V93.3.1032>
5. Kobayashi, M., Horikawa, M., Uehara, T., Honda, T., Kobayashi, T., Sakai, H. (2015) Flower-like/clover leaf lymphocytes appear in various diseases: Cerebrospinal fluid cytology case with review of the literature. Diagn. Cytopathol. 43, 88–90. <https://doi.org/10.1002/dc.23147>
6. Liu, K., Song, H., Shi, J., Zhang, W., Mu, R., Li, L. (2020) Rare case of plasma cell myeloma with megakaryoblastic morphology mimicking acute leukemia. Indian J. Pathol. Microbiol. 63(3), 485–487. <https://doi.org/10.4103/IJPM.IJPM_282_19>
7. Sall, A., Seck, M., Samb, D., Faye, B., Gadji, M., Diop, S., Touré, A. O. (2021) Flower-like plasma cell nuclei in multiple myeloma. Turk. J. Haematol. 38(2), 153–154. <https://doi.org/10.4274/tjh.galenos.2020.2020.0471>
8. Shibusawa, M. (2020) Plasma cell leukaemia presenting as flower-shaped plasma cells mimicking adult T-cell leukaemia or lymphoma. Lancet Haematol. 7, e270. <https://doi.org/10.1016/S2352-3026(20)30037-5>
9. Singh, N., Gandhi, J., Agrawal, N., Panaych, A., Tejwani, N., Mehta, A. (2017) Diagnostic dilemma in the morphological detection of flower cells in lymphomas. Indian J. Hematol. Blood Transfus. 33(4), 614–616. <https://doi.org/10.1007/s12288-017-0782-3>
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ISSN 1214-6994 (Print) ISSN 2336-2936 (Online)

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