Prague Med. Rep. 2026, 127, 225-228
Siliconomas and Sepsis from Illegal Silicone Injections
, Gianmichele Muscatella1, Federica Masino1, Alessio Sciacqua1, Marina Balbino1, Rossella Gifuni1, Giuseppe Guglielmi1,2,3
1Department of Clinical and Experimental Medicine, School of Medicine, University of Foggia, Foggia, Italy
2Radiology Unit, “Dimiccoli” Hospital, Barletta, Italy
3Radiology Unit, IRCCS “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy
Received November 26, 2024
Accepted September 8, 2026
Illegal silicone injections for body enhancement can lead to serious complications, including the formation of siliconomas – granulomatous reactions caused by silicone leakage and spread through tissues and lymphatic drainage pathways. This paper presents the case of a 31-year-old transgender man who developed widespread silicone-related soft tissue deposits and sepsis following unauthorized silicone injections into the gluteal region. The patient presented with fever, hypotension, tachycardia, and multiple palpable subcutaneous nodules. Imaging studies, including computed tomography, magnetic resonance imaging, and ultrasound, demonstrated extensive silicone deposits and regional lymphadenopathy. Sepsis was diagnosed and managed with intravenous antibiotics and surgical consultation. This case highlights the dangers of unregulated silicone injections and the importance of early imaging to assess the extent of complications.
Keywords
Silicone injection, Siliconoma, Sepsis, MRI, CT scan, Lymphadenopathy.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
