Prague Med. Rep. 2012, 113, 16-22

https://doi.org/10.14712/23362936.2015.33

Lack of Association between Interleukin-18 –607 C/A Gene Polymorphism and Pulmonary Tuberculosis in Zahedan, Southeast Iran

M. Taheri1,2, S. M. Hashemi-Shahri3, M. Hamzehnejadi3, M. Naderi3, A. Moazeni-Roodi3, G. Bahari4, Mohammad Hashemi1,4

1Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2Department of Genetics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Received June 30, 2011
Accepted January 16, 2012

Interleukin-18 (IL-18) plays a critical role in immune response, contributing to the pathogenesis and pathophysiology of infectious diseases. Polymorphisms in the IL-18 genes are known to influence expression levels and may be associated with outcome of infections. The objective of this study was to determine whether the presence of IL-18 polymorphisms –607 A/C (rs1946518) was associated with tuberculosis disease. We investigated the functional polymorphism of IL-18 (rs1946518) in 174 patients with pulmonary tuberculosis (PTB) and 177 healthy subjects. Genotype analysis was done using tetra amplification refractory mutation system-PCR (T-ARMS-PCR). The allelic and genotypic frequencies of the IL-18 polymorphism did not differ significantly between PTB and the controls. Our finding suggests that IL-18 polymorphism (rs1946518) may not be a risk factor for susceptibility to tuberculosis in a sample of Iranian population. Further studies are required to validate our findings.

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