Prague Med. Rep. 2012, 113, 217-222

https://doi.org/10.14712/23362936.2015.19

Association of –607 C/A Polymorphism of IL-18 Gene (rs1946518) with Breast Cancer Risk in Zahedan, Southeast Iran

M. Taheri1,2, Mohammad Hashemi2,3, E. Eskandari-Nasab2, A. Fazaeli2, F. Arbabi4, M. Bahrani-Zeidabadi3, G. Bahari3

1Department of Genetics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
3Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Received January 18, 2012
Accepted June 25, 2012

It is known that interleukin-18 (IL-18) is a proinflammatory cytokine with dual effects on tumor development and progression. It can increase the immune defense against tumor cells. Polymorphisms in the IL-18 genes are known to influence both expression levels and may be associated with outcome of cancers. This study was aimed to find out the possible association of IL-18 polymorphism at position –607 C/A (rs1946518) with breast cancer in a sample of Iranian population. We investigated IL-18 rs1946518 polymorphism on 72 breast cancer patients and 93 cancer free women. Genotyping was done using amplification refractory mutation system-PCR (ARMS-PCR). We found no significant differences between breast cancer patients and control subjects regarding IL-18 rs1946518 polymorphism (χ2=1.78, p=0.411). In conclusion, our finding showed that IL-18 rs1946518 polymorphism was not associated with breast cancer in a sample of Iranian population.

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