Prague Med. Rep. 2015, 116, 40-48

Daily Profiles of Dehydroepiandrosterone and Its Hydroxylated Metabolites with Respect to Food Intake

Luboslav Stárka, Beata Rácz, Monika Šrámková, Martin Hill, Michaela Dušková

Institute of Endocrinology, Prague, Czech Republic

Received January 23, 2015
Accepted March 12, 2015

Eight women of reproductive age with normal body mass index were given 5 standardised meals, and their hormonal milieu was determined during the course of the day. Plasma from 12 withdrawals was analysed for dehydroepiandrosterone and its 7- and 16-hydroxylated metabolites. Overall, there was a maximum in the levels of steroid hormones in the morning, followed by decreases throughout the day. There was also an additional significant decrease found for dehydroepiandrosterone and its 7α-hydroxyderivative in association with the consumption of main meals, but not for the 7β-isomer or 16α-hydroxyderivative.


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