Prague Med. Rep. 2019, 120, 52-63
Pharmacokinetics of Dasatinib
Tyrosine kinase inhibitors have recently become an essential tool in management of chronic myeloid leukaemia (CML). Dasatinib, a representative of those drugs, acts by inhibiting key proteins included in CML development, predominantly Bcr-Abl and Src. Its advantage is that it shows activity in many cases where other agents bring no improvement due to resistance. Pharmacokinetics of dasatinib has specific characteristics that may play an important role in achieving sufficient exposure in patients. Therefore, the key pharmacokinetic properties are summarized in this report. For example, dasatinib absorption is significantly influenced by gastric pH and its modulation can be a source of serious interactions, as well as simultaneous administration of drugs affecting cytochrome P450.
Keywords
Dasatinib, Pharmacokinetics, pH-dependent absorption, Drug interaction.
Funding
This study was supported by the Charles University Project Progres Q25 and a grant no. SVV 260373.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
