Prague Med. Rep. 2022, 123, 27-34
POEMS Syndrome Diagnosis in a Patient with Mixed Polyneuropathy: Case Report
POEMS syndrome is a rare condition of paraneoplasic origin characterized by the presence of a sensorimotor polyneuropathy associated with the presence of a proliferative disorder of plasmatic monoclonal cells and overproduction of vascular endothelial growth factor. The acronym “POEMS” represents multisystem findings including polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes; nevertheless, clinical presentation is heterogeneous. We describe a clinical case, the diagnostic and therapeutic approach in a patient with sensorimotor polyneuropathy in whom POEMS syndrome was diagnosed; to understand this pathology, its clinical and paraclinical manifestations in order to make a diagnosis or to avoid a delayed one and to provide an adequate treatment.
Keywords
Paraproteinemia, POEMS syndrome, Plasma cells, Plasmocytoma, Polyneuropathy.
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Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
