Prague Med. Rep. 2023, 124, 242-254

https://doi.org/10.14712/23362936.2023.19

The Predictive Value of Serum Aldosterone Level for Coronary Artery Calcium Score in Patients with Chronic Kidney Disease: A Single-center Study

Viktor V. Semenov1, Jizzo R. Bosdriesz2, Olexandr Kuryata1

1Department of Internal Medicine 2 and Phthisiology, Dnipro State Medical University, Dnipro, Ukraine
2ERA-EDTA Registry, Department of Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands

Received September 21, 2022
Accepted August 27, 2023

Patients with chronic kidney disease (CKD) have high cardiovascular risk (CVR), which is often underestimated by conventional tools. The coronary artery calcium score (CACS) significantly improves CVR stratification by conventional tools, but it is often not available in low-resources settings. Aldosterone may be a cheaper alternative to CACS for CVR assessment in CKD patients. The aim was to assess the ability of serum aldosterone level to predict CACS in patients with CKD in comparison to standard predictors. This single-center study included 57 patients aged 40 to 67 years with CKD (estimated glomerular filtration rate [eGFR] ≥45 ml/min) and arterial hypertension. Serum aldosterone, sex, age, body mass index, blood pressure, total cholesterol, eGFR, and proteinuria were used for prediction of CACS>0 Agatston units (AU) and CACS>100 AU. The area under the curve (AUC) with 95% confidence intervals (CI) and the mean Brier scores were examined for predictors of CACS. Aldosterone predicted a CACS>100 AU (AUC = 0.72, 95% CI: 0.56–0.88), but not a CACS>0 AU. Age predicted a CACS>100 AU (AUC = 0.80, 95% CI: 0.67–0.93) and a CACS>0 AU (AUC = 0.75, 95% CI: 0.62–0.89). The addition of aldosterone to age for prediction of a CACS>100 AU improved the mean Brier score, compared to the model with age alone, from 0.16 to 0.14, but not the AUC (0.83, 95% CI: 0.70–0.95). Aldosterone was a significant predictor of a CACS>100 AU in patients with CKD, but aldosterone was not a better predictor than age alone.

Funding

This study was supported from European Renal Association – European Dialysis and Transplantation Association during ERA-EDTA Registry Fellowship at the Department of Medical Informatics, Amsterdam UMC, University of Amsterdam. The reagent for measurement of serum aldosterone was purchased with the support from Dnipro State Medical University, Dnipro, Ukraine.

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