Prague Med. Rep. 2024, 125, 5-14

https://doi.org/10.14712/23362936.2024.1

Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis

Hamidreza Kouhpayeh1, Mohammad Naderi1, Zahra Mohammadghasemipour1, Gholamreza Bahari2, Nastaran Elahian3, Mohsen Taheri3,4, Mohammad Hashemi3

1Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
3Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
4Department of Genetic, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Received September 4, 2023
Accepted January 30, 2024

There is little data regarding the impact of renin-angiotensin system (RAS) gene polymorphisms on tuberculosis. The current study designed to survey the possible association between RAS polymorphisms and the risk of pulmonary tuberculosis (PTB) in a sample of the southeast Iranian population. This case-control study was done on 170 PTB patients and 170 healthy subjects. The AGT rs699 C>T, ACE rs4341 C>G and AT1R rs5186 C>A variants were genotyped using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and ACE rs4646994 (287bp I/D) variant by PCR method. Regarding AT1R rs5186 A>C polymorphism, the findings revealed that AC genotype and C allele significantly decreased the risk of PTB (OR=0.39, 95% CI=0.22–0.67, p=0.001, and OR=0.53, 95% CI=0.25–0.72, p=0.002, C vs. A, respectively). The TC genotype and C allele of AGT rs699 T>C significantly associated with decreased the risk of PTB (OR=0.45, 95% CI=0.28–0.74, p=0.002, TC vs. TT and OR=0.51, 95% CI=0.32–0.80, p=0.005, C vs. T, respectively). The ID genotype of ACE 287bp I/D significantly increased the risk of PTB (OR=1.88, 95% CI=1.12–3.17, p=0.017). Our finding did not support an association between ACE rs4341 C>G variant and the risk of PTB. In summary, the findings revealed an association between AT1R rs5186 A>C, AGT rs699 T>C and ACE 287bp I/D polymorphisms and the risk of PTB in a sample of the southeast Iranian population. Further investigation with higher sample sizes and diverse ethnicities are required to confirm our findings.

Funding

This study was supported by a dissertation research grant (M.D. thesis of ZMG #8299) from Zahedan University of Medical Sciences.

References

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