Prague Med. Rep. 2024, 125, 256-263

https://doi.org/10.14712/23362936.2024.23

A Rare Case of Primary Vulval Amelanotic Melanoma Involving the Urethra

Manuela Montatore1, Laura Eusebi2, Federica Masino1, Alessia Mariagrazia Costa3, Willy Giannubilo3, Ferioli Elena4, Lucilla Diamanti4, Giuseppe Guglielmi1,5,6

1Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, Italy
2Radiology Unit, “Carlo Urbani” Hospital, Jesi, Italy
3Department of Urology, Ospedale Civile, Civitanova Marche, Italy
4Pathological Anatomy Unit, Ospedale di Macerata, Macerata, Italy
5Radiology Unit, “Dimiccoli” Hospital, Barletta, Italy
6Radiology Unit, “IRCCS Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy

Received June 7, 2024
Accepted July 28, 2024

A 60-year-old woman came to the Emergency Department complaining of a vaginal formation. The urologist suspected a urethral caruncle: the patient was discharged with vaginal oestrogen cream to relieve symptoms and a follow-up was suggested. After two months the patient returned to the Emergency Department since the mass was increasing in volume and complaining of dysuria and haematuria. Ultrasound, contrast-enhanced computed tomography, and contrast-enhanced magnetic resonance revealed a mass arising from the mucosa and involving the vulva and the urethra, suspicious of malignancy. We present a challenging diagnosis of an infiltrative and rapidly progressive primary vulval amelanotic melanoma with a complete imaging evaluation and a confirmed histological diagnosis.

References

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